Protein Details: Voltage-gated potassium channel subunit beta-3

Protein ID

ICDB_Pro_1598

Protein Name

Voltage-gated potassium channel subunit beta-3

Gene Name

kcnab3; kvb-B; kvb4

Organism

Xenopus laevis (African clawed frog)

Length

401 amino acids

AlphaFoldDB

AF-Q9PTM4-F1-model_v4.pdb

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.1 and Kv1.2

Sequence

MQVSFACTEQTLRSRTSEDRLCPSRPSGGQNGVSMAQTKQRTPPMGAKNHNQVLPLLSHILRESTVKSTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDEVAENLMTVAYEHGVNLFDTAEVYAAGRAERTLGKILKKKEWRRSSYVVTTKIYWGGQAETERGLSRKHIIEGLRGSLERLQLDYVDIVFANRMDPNSPMEEIVRAMTFVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVETQLPELYHKIGVGSMTWSPLACGLITGKYTDTVPEKSRASFKGYHWLKEKAISQEGKKQHSKVKELHPIADRLNCTVTQLAIAWCLRSEGVSSVLLGVSNIEQLLENLGAIQVLPHLTPQLVTEIDQILGNKPNLKKDSRA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

90;91;97;119;192;222;223;248;277;278;279;280;281;282;288;298;357;359;363;366;367

Disease

Location

Expression first detected in brain and most anterior regions of spinal cord at embryonic stage 24 (26 hours). By stage 29 (35 hours) expression is also detected in posterior regions of spinal cord.

DOI ID

10.1523/jneurosci.19-24-10706.1999

RefSeq

XP_018109269.1